Exterminators are a subset of Safeguard that often appear as black and white humanoid machines. They use primitive weaponry, often their claws or melee weapons, though stronger versions are capable of energy attacks. There are many different versions of Exterminators, the most prominent being the Class One. It is capable of telekinesis, regeneration, and beam attacks.

They often attack in greater numbers and resemble a zombie horde while doing so. But also a handful can pose a serious threat to anyone without the Net Terminal Gene. This is because they possess a strong Exoskeleton which can't be penetrated by normal weapons.